Deby Mardhian, MSc

Position: PhD Student    
Education: MSc Materials Science          
In the Lab since: 2016
Main Research: Targeting Fibrotic Tumor Microenvironment
Research Interests: - Tumor Stroma
                                    - Nanocarriers
                                    - Bioactive molecules                                 
My Personal Goal: ''Modulating fibrotic tumor microenvironment by combining bioactive molecules and strategy of delivery''

Contact:  d.f.mardhian@utwente.nl
Location: ZH 255

My research

I am working on the modulation of pancreatic tumor (fibrotic tumor). Pancreatic ductal adenocarcinoma (PDAC) is one of the highly malignant and deadliest tumor type comprised of up to 90% tumor stroma which takes parts in promoting tumor, metastasis, and angiogenesis as well as acts as barrier for chemotherapy. The approach carried out in this project is to target stromal barrier to increase the efficacy of chemotherapy.

About me

In 2012, I obtained my bachelor degree in chemistry from Institut Teknologi Bandung, Indonesia. At the same institute, I continued my study for my master degree in materials science and focused in ceramics and graduated in 2014. Afterwards, I became a lab assistant in the lab where I worked my thesis project for a year. I was to help undergraduate students to perform their projects. I started to have an interest in biomaterials and drug delivery at that time. In 2015, I was rewarded a scholarship from LPDP Indonesia to continue in PhD. I started my PhD in 2016 in the group of Jai Prakash (Targeted Therapeutics), funded by LPDP Indonesia.

Publications
2018

Mardhian DF., Storm G., Bansal R., Prakash J.
''Nano-targeted relaxin impairs fibrosis and tumor growth in pancreatic cancer and improves the efficacy of gemcitabine in vivo.''
J. Control. Release 2018 Oct 2;290:1-10. doi: 10.1016/j.jconrel.2018.09.031.
PMID: 30287265